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Sunshine

The all-around LNP process developer

Scale it up

Once you’ve found a rock-solid formulation, Sunshine helps you tune in your LNP’s size and design the perfect process to scale them up. Scout ideal flow rates, explore different mixing options, then dial in the right dilution factor to keep them stable. When you’ve got everything just right, Sunshine can shift into continuous mode, making tens of liters in a day. Get process development and scale-up on one platform — who would have figured? Get brochure.

  • 10 experiments in 15 minutes
  • Fractional & total flow rates
  • 1 mL to continuous flow
  • 0.1 — 30 mL/min flow rates
  • Reusable microfluidics
  • Protocol transfer from Sunscreen

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Video

Watch Sunshine in action.

Find your flow

Fill one syringe with payloads, the other with lipids and you’re ready to mix them up with a Sunny. For a simple, well-known T-mixing approach or to increase fluid contact area for particle formation with a cross-junction, grab a Sunny XT. To use Sunshine’s full range of flow rates, ratios and integrated in-line dilution, choose a Sunny Trident. Sunnies can be subbed in and out of Sunshine, used over and over, and when you’re ready to turn up the volume, they can run longer than you can.

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Fine-tune it fast

Tell Sunshine’s Sunny Suite Software what’s in your syringes, the lipid to payload ratios, the flow rates you want to mix at, how much diluent you want to add and you’re ready to go. The software checks to make sure your experiments will work, so you don’t need to worry about screwing things up. Create 10 different samples in 15 minutes or let Sunshine run for hours while it makes liters of LNPs.

Dial it in

From their ability to get inside of cells, to releasing their payload, size really does matter when it comes to LNPs. Sunshine fully automates the fractional flow rate, total flow rate and dilution experiments that helps you size them down and keep them stable, with spot on repeatability. Tinker with up to 10 parameters per run and let Sunshine take it from there.

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Bulk it up

Sunshine is ready when you are to start making large volumes of LNPs. Whether you’re making milliliters or liters, your sizes and PDIs will stay consistent — no matter how much you decide to make.

Trust the process

From screening to development to scale up, Sunscreen and Sunshine have your LNPs covered. The methods and Sunnies can be handed off from platform to platform, so you can trust you’ll get high quality LNPs every step of the way.

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Learn more

Webinars

LNP formulation just got sunnier with the Sunny Suite

Ben Knappett, PhD, Product Manager, LNP Solutions, Unchained Labs

App Notes

Process optimization and pre-clinical production of lipid nanoparticles using Sunshine
Flexible nanoparticle development: process optimization & scale-up of a wide range of synthetic nanomedicines with Sunshine

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