Formulation & polymorph screening
Characterization of Active Pharmaceutical Ingredients (APIs) goes beyond knowing the chemical structure. APIs can crystallize into different forms (polymorphs), each of which have their own solubility, bioavailability, and hydration stability. From an intellectual property standpoint, it’s also critical for researchers to identify all polymorphs for their API — before someone else does. All this means that it’s not enough to discover a new API. It’s also important to characterize it fully, by figuring out what conditions make it crystallize, and in which forms. This requires extensive polymorph screening by exploring a lot of conditions to generate crystals, including not just solvents but understanding how the presence of salts or potential co-crystals impact the crystal polymorph. Polymorph screening is a ton of work that usually requires a small army to get it all done.
The right tool for the job
Heated liquid dispense
Heated filter block
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