UNcle front-transparent_2


The first all-in-one biologics stability screening platform

One-stop stability

Cracking stability using a pile of one-trick, protein-hungry tools is a ton of work. Uncle combines 3 different measurement modes — fluorescence, Static Light Scattering (SLS) and Dynamic Light Scattering (DLS). So you can crank out all your data in just a few hours, and use way less protein. All the info you’ll get makes picking the best formulation, protein, or viral vector a piece of cake. Get brochure.

  • Tm & T agg
  • Tm with SYPRO (DSF)
  • Isothermal stability
  • Sizing & polydispersity
  • Sizing with thermal ramp
  • Thermal recovery
  • Viscosity
  • kD
  • B22
  • G22
  • ΔG
  • Viral capsid stability

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Watch Uncle in action.

Uncover way more in one shot

Trying new formulations or constructs? Get answers for up to 48 samples in under 2 hours. Measure Tm and Tagg at the same time and know when unfolding leads to aggregation. Add a DLS read before the temp ramp to know if you’ve got aggregate trouble right out of the gate.


AAV capsid stability

Uncle teams up with SYBR Gold to get a read on when your DNA starts to leak — way before the AAV capsid pops. Quantify initial free DNA and the amount that’s on the loose after a thermal ramp. Know when aggregation gets out of hand and tackle particle titer with SLS and DLS.

B22 & kD

Get B22 and kD at the same time in the same Uni. Or, switch over to G22 if you’re working at super high concentrations. Learn on the spot if your protein-formulation combo is good to go or risky for aggregation with software that makes things easy to figure out. For super high protein concentrations, G22 is ready to go.


Unleash the Uni

Get more data with way less protein. The Uni only needs 9 μL of sample, and you pick how you use it. Run 1 sample in the morning, 48 in the afternoon. Do a DLS read if that’s all you need. Or, check DLS, then start a 3-day experiment to monitor real-time stability. Your samples are sealed airtight, so runs can be short or long — your call.


Biologics behave differently. With Uncle, you get the whole fluorescence spectrum, so you don’t need to know ahead of time how your protein behaves. If you want to try out some new tricks with dyes, Uncle can pick up on those too. Uncle catches aggregation with two wavelengths — so you’ll see it no matter what.



If you’re working in regulated environments, you know that controlling access to data and keeping its integrity are a must-have. Uncle has 21CFRp11 compliant software tools that can be turned on without a hitch.

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Beef up your protein formulation toolbox with Uncle

Kevin Lance, PhD, Marketing Manager, Analytical Instruments, Unchained Labs

See when your AAV hits the eject button with Uncle

Kevin Lance, PhD, Marketing Manager, Unchained Labs

Improving antibody drug candidate success through developability assessments

Jacek Ostrowski, PhD, Associate Director, Protein Chemistry, AlivaMab Discovery Services
Kevin Lance, PhD, Marketing Manager, Analytical Instruments, Unchained Labs

Thermal unfolding and aggregation analysis of lead antibodies and variants derived from synthetic antibody libraries

Aaron K. Sato, Ph.D., CSO Biopharma, Twist Biopharma, a division of Twist Bioscience
Kevin Lance, Ph.D., Marketing Manager, Unchained Labs

App Notes

Meet our Uncle: 12 stability applications on one platform
DNA leaks before capsids pop: AAV thermal stability on Uncle
Size matters in Uncle’s Sizing with Thermal Ramp app
See it all with Uncle’s full-spectrum analysis
Assess aggregation risk at higher protein concentrations with G22


Differential Scanning Fluorimetry (DSF)
Static Light Scattering (SLS)
Dynamic Light Scattering (DLS)


Download Uncle Software

Want a quote or a demo?