Stunner

product

Stunner

The one and only biologics quantification and quality combo.

Quant and sizing mash up

Stunner pulls double-duty so you don’t have to. It’s the only system out there that takes UV/Vis concentration and Dynamic Light Scattering (DLS) size measurements from the same sample at the same time. Nail down your protein quality by knocking concentration, hydrodynamic size, polydispersity, and detection of aggregates off your list in one shot. Without skipping a beat, you can also measure the colloidal stability of your samples or design your own custom apps. Get brochure.

Concentration

Sizing

Polydispersity

B22

kD

Homebrew

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Teeny sample, tons of info

Just load 2 μL of sample in a Stunner plate — don’t bother with sample prep or dilution. Each microfluidic circuit has two fixed pathlengths built into it to cover a wide dynamic range of 0.03-275 OD. If you’re dealing with a full plate, get 96 concentration measurements in 10 minutes — add on DLS sizing and have both done in an hour. For even heavier workflows, hook it up to your favorite robot to add more oomph.

DLS and then some

Stunner pulls rank on other systems because it’s way, way more than just DLS. It lets you get a grip on what storage, agitation or a change to your process or formulation does to your protein. See if there’s any aggregation, measure the hydrodynamic size, grab polydispersity when you need to check uniformity, and get the exact concentration while you’re at it.

Max out your biologic

Stunner is the only system out there that can measure biologics at high-throughput and high concentration. It’s got dynamic range that covers from 0.02 mg/mL to 200 mg/mL (mAb), so run any protein without ever having to dilute again. Stop the madness of running just one protein at a time — and cleaning up afterwards.

Ridiculously good data

Get spot-on precision within 1% and accuracy within 2%. Using two fixed pathlengths, Stunner gets you jaw-dropping data at both low and high protein concentrations and nails the expected concentrations every time. With the smallest sample size, the highest throughput and crazy accurate results, Stunner is hands down the best tool out there for protein quantification.

Double down with B22 and kD

On the fly data tells you if your sample’s in good shape, or if aggregation is in the cards. Because the concentration of each sample in the series is measured in real time with DLS, you get the most accurate values without breaking a sweat.

Brew your own

Pin down what else is going on with your sample, or just check out its other characteristics. Pick a few wavelengths, a background subtraction method, and create your favorite equation. Stunner’s Homebrew tool is wide open, so you can create apps just the way you like them.

Accuracy you can show off

Stunner has shocking accuracy and wants to prove it. Using the Fundamentals tryptophan standards, the accuracy, precision and linearity of the instrument can be proven at any time – at the protein-relevant 280 nm wavelength and OD range of 20-225. Be confident about every sample with data that leaves no room for doubt.

Downstream ready

Smash through the USP & Ph. Eur. UV/Vis requirements for absorbance accuracy, precision, linearity, wavelength accuracy, stray light and resolution with performance verification measurements of independently certified NIST standards. Stunner is ready when you are to get validated and make the move into QC.

Put it on lockdown

GLP labs don’t sweat it. Stunner’s software hooks labs up with 21 CFR Part 11 compliant features. We’re talking password protection, electronic signatures, full audit trail — the whole package.

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