Apr 1, 2020
Unchained Labs jumps into gene therapy and vaccines with new AAV stability application! Read more.
Unchained Labs jumps into gene therapy and vaccines with new AAV stability application!
April 1, 2020 – Pleasanton, CA – Unchained Labs, the life sciences company that’s all about getting biologics researchers the right tool for the job, launched its new AAV stability application on the Uncle platform today. Uncle is already the gold standard for measuring protein stability and, with this new application, jumps in to support researchers in pursuit of novel gene therapies and better vaccines.
Many gene therapies, immunotherapies and vaccines being developed use adeno-associated viruses or AAVs. These viral vectors are great at sneaking past the body’s immune system to deliver DNA that commands cells to make proteins that end diseases or antibodies that seek out and destroy viruses. A stable AAV stays intact until it finds its target and won’t aggregate – or worse, leak potentially toxic DNA into the body.
Uncle’s newest application helps researchers understand their AAV stability. It uses a thermal ramp with a DNA-binding fluorescent dye to help them get a read on when DNA starts to leak from an AAV, even before the capsid starts to fall apart. Uncle’s DLS and SLS combo can measure the particle titer to see how many capsids they have. They’ll also know when aggregation gets out of hand.
“With this new application, Uncle lends a helping hand to researchers working on life-changing gene therapies and vaccines,” said Taegen Clary, VP of Marketing at Unchained Labs. “With deeper insights into AAV stability, researchers can now screen and refine their capsids for strength, find the best formulations, and optimize storage conditions, all with a single instrument.”
About Unchained Labs
Here’s the deal. We’re all about helping biologics researchers break free from tools that just don’t cut it. Unleashing problem-tackling products that make a huge difference in the real science they do every day. That’s our mantra, our promise and we own it. We’re located in Pleasanton, CA and can be found online at www.unchainedlabs.com.
Contact:
Taegen Clary
VP of Marketing, Unchained Labs
taegen.clary@unchainedlabs.com
925.587.9806
Download PDF of press release.
Jul 30, 2019
Unchained Labs keeps on bringing it with Uncle 4.0! Read more.
Unchained Labs keeps on bringing it with Uncle 4.0!
July 30, 2019 – Pleasanton, CA – Unchained Labs, the life sciences company that’s all about getting biologics researchers the right tool for the job, rolled out its Uncle 4.0 software today. This release is chock-full of new data analysis tools and expands the biologics application space for Uncle, the undisputed all-in-one stability screening platform.
When developing a protein or formulation, aggregation is always a no-go. Right from the start, Uncle’s been giving researchers insight into the connection between protein unfolding and aggregation with its combo of fluorescence and static light scattering. Uncle 4.0 software helps them dig even deeper with a beefed-up dynamic light scattering application that grabs more data points during thermal ramps. The higher resolution that comes with it gives scientists a much closer look at aggregation events.
Uncle’s always delivered the complete protein stability story using full-spectrum fluorescence. The Uncle 4.0 update lets researchers choose exactly what part of the spectrum they want to analyze, so they can focus in on even subtle changes happening to their protein. Being able to dial up a specific wavelength band of interest gives them the option to work with many fluorescent dyes, making it possible to characterize membrane proteins and other tricky molecules.
“Uncle didn’t become the gold standard for assessing protein stability overnight,” said Taegen Clary, VP of Marketing at Unchained Labs. “We listen to our customers and their input is all over this software update. It’s packed with all kinds of analysis tools and capabilities that will let them score info they haven’t been able to before.”
About Unchained Labs
Here’s the deal. We’re all about helping biologics researchers break free from tools that just don’t cut it. Unleashing problem-tackling products that make a huge difference in the real science they do every day. That’s our mantra, our promise and we own it. We’re located in Pleasanton, CA and can be found online at www.unchainedlabs.com.
Contact:
Taegen Clary
VP of Marketing, Unchained Labs
taegen.clary@unchainedlabs.com
925.587.9806
Download PDF of press release.
Jul 16, 2019
Unchained Labs takes the panic out of particle ID, launches its new Hound! Read more.
Unchained Labs takes the panic out of particle ID, launches its new Hound!
July 16, 2019 – Pleasanton, CA – Unchained Labs, the life sciences company that’s all about getting biologics researchers the right tool for the job, launched the new Hound today. Hound is the only platform out there that combines a trifecta of lasers into a single instrument, cementing its status as the go-to platform for particle identification in quality control.
Nothing freaks out a drug manufacturer more than seeing mysterious particles floating in their product. Hound identifies the chemical fingerprints for a wide range of organics like fibers or protein aggregates using red and green Raman. For inorganic particles like glass and metal fragments, Hound brings in Laser Induced Breakdown Spectroscopy (LIBS) to nail the ID based on the elemental makeup. Scientists can now rest easy knowing that Hound can get them out of any jam.
“Our new Hound builds on what was already an indispensable particle ID tool for our customers,” said Taegen Clary, VP of Marketing at Unchained Labs. “The hardware and software have been completely overhauled, making the platform super easy to use and the total package for particle identification.”
About Unchained Labs
Here’s the deal. We’re all about helping biologics researchers break free from tools that just don’t cut it. Unleashing problem-tackling products that make a huge difference in the real science they do every day. That’s our mantra, our promise and we own it. We’re located in Pleasanton, CA and can be found online at www.unchainedlabs.com.
Contact:
Taegen Clary
VP of Marketing, Unchained Labs
taegen.clary@unchainedlabs.com
925.587.9806
Download PDF of press release.
May 13, 2019
Unchained Labs gets teed up for the future, snags $50 million debt facility with Silicon Valley Bank Read more.
Unchained Labs gets teed up for the future, snags $50 million debt facility with Silicon Valley Bank
May 13, 2019 – Pleasanton, CA – Unchained Labs, the life sciences company that’s all about getting biologics researchers the right tool for the job, today announced it has closed a $50 million debt facility from Silicon Valley Bank (SVB) to further support its working capital growth, along with adding dry powder for future acquisitions.
The agreement allows the company to retire its existing $18.5 million debt facility and complements the $86 million raised in equity over the last four years from Novo Ventures, Canaan Partners, TPG Biotech and Tri-Valley Ventures.
“We are thrilled to partner with Unchained Labs,” said Kristina Peralta, Vice President, Life Sciences at Silicon Valley Bank. “We are proud to support a team that is paving the way for better biologics research and therapeutic options.”
“We are fired up about the opportunity to work with SVB as we continue to scale our business around the globe,” said Jason Novi, Chief Financial Officer of Unchained Labs. “This financing supports our mission to build the largest biologics tools pure-play out there.”
About Unchained Labs
Here’s the deal. We’re all about helping biologics researchers break free from tools that just don’t cut it. Unleashing problem-tackling products that make a huge difference in the real science they do every day. That’s our mantra, our promise and we own it. We’re located in Pleasanton, CA and can be found online at www.unchainedlabs.com.
Contact:
Taegen Clary
VP of Marketing, Unchained Labs
taegen.clary@unchainedlabs.com
925.587.9806
Download PDF of press release.
Jan 15, 2019
Unchained Labs cuts the ribbon on new contract testing lab in North America! Read more.
Unchained Labs cuts the ribbon on new contract testing lab in North America!
January 15, 2019 – Pleasanton, CA – Unchained Labs, the life sciences company that’s all about getting biologics researchers the right tool for the job, opened the doors to its new contract testing lab today. The lab is located at the company’s headquarters in Pleasanton, California and provides identification of unwanted particles in drug products and quality assessment of the silicone layers on drug delivery devices.
Two Unchained Labs instruments are heavily used for contract testing. For visible particles, Hound determines the count, size, shape and identity with either Raman or LIBS spectroscopy. If clients have particles in the sub-visible range, the lab has the tools to hunt down those too. Bouncer is used to measure the silicone thickness and distribution on syringes, cartridges and vials.
All sample preparation and testing are handled by trained experts who deliver detailed reports that document the test plan, measurement parameters and results. Turnaround time for results can be as quick as 3 days.
“If someone has particle problems or wants to confirm that the right amount of silicone is on their device, we’ve got their back,” said Taegen Clary, VP of Marketing at Unchained Labs. “The new Pleasanton contract testing lab makes it easier for more customers in North America to take advantage of these services and expands capacity beyond our current test lab in Europe.”
About Unchained Labs
Here’s the deal. We’re all about helping biologics researchers break free from tools that just don’t cut it. Unleashing problem-tackling products that make a huge difference in the real science they do every day. That’s our mantra, our promise and we own it. We’re located in Pleasanton, CA and can be found online at www.unchainedlabs.com.
Contact:
Taegen Clary
VP of Marketing, Unchained Labs
taegen.clary@unchainedlabs.com
925.587.9806
Download PDF of press release.
Nov 5, 2018
Unchained Labs takes the chore out of buffer exchange, reels in the Big Tuna! Read more.
Unchained Labs takes the chore out of buffer exchange, reels in the Big Tuna!
November 5, 2018 – Pleasanton, CA – Unchained Labs, the life sciences company that’s all about getting biologics researchers the right tool for the job, launched Big Tuna today – the ultimate automated solution for buffer exchange – a mission-critical step in biologics formulation.
The buffer exchange process moves proteins from one solution into another and is used to find the best condition to keep them stable. It’s a major bottleneck and quality concern for protein characterization, development and formulation teams. Because the process needs lots of hands-on time and eyeballing to do it right, it’s one of the most annoying things researchers have to do.
Big Tuna solves all of this. It wipes the bottleneck by letting scientists automate buffer exchange at whatever throughput they want – just a few samples or up to 96 simultaneously. It nails quality using a unique pressure-based exchange process that lets scientists pick how slow or fast they want their protein to move between solutions. Final protein concentration is dead-on, cutting out extra steps usually required after manual buffer exchange. Big Tuna is also the only system that exchanges anywhere from 100 µL to 8 mL at a time, so it’s right at home in any stage – from early screening and optimization to final formulation development.
“Biologics researchers have bigger fish to fry than buffer exchange,” said Taegen Clary, VP of Marketing at Unchained Labs. “Big Tuna provides complete relief from one of their biggest pains in the neck. It eliminates the whole hands-on process and delivers better results to boot.”
About Unchained Labs
Here’s the deal. We’re all about helping biologics researchers break free from tools that just don’t cut it. Unleashing problem-tackling products that make a huge difference in the real science they do every day. That’s our mantra, our promise and we own it. We’re located in Pleasanton, CA and can be found online at www.unchainedlabs.com.
Contact:
Taegen Clary
VP of Marketing, Unchained Labs
taegen.clary@unchainedlabs.com
925.587.9806
Download PDF of press release.
Oct 8, 2018
Unchained Labs blows minds with biologic quant and quality mashup, launches Stunner! Read more.
Unchained Labs blows minds with biologic quant and quality mashup, launches Stunner!
October 8, 2018 – Pleasanton, CA – Unchained Labs, the life sciences company that’s all about getting biologics researchers the right tool for the job, launched Stunner today — the first instrument to combine protein concentration and size-based quality measurements under the same hood.
Every day, biologics researchers ask themselves two critical questions about their samples: How much protein do I have, and is it in good shape? To get the answers, they typically need to run experiments on multiple instruments, which eats up time and sample. Stunner gives them both in one shot by combining UV/Vis concentration and Dynamic Light Scattering (DLS) quality measurements from the same tiny sample.
Stunner gives scientists the best of two worlds — the dead-on UV/Vis accuracy Unchained Labs’ Lunatic is known for, and the company’s fresh take on DLS technology, which is super easy to use compared to other systems out there. With just 2 µL, Stunner bangs out concentration and quality measurements like hydrodynamic size, polydispersity and detection of aggregates in 1 minute. Researchers dealing with a full plate can knock out 96 samples in an hour. For heavy duty workflows, they can hook Stunner up to their favorite robot to add more zip.
“Biologics researchers have needed a solution like this forever, which makes Stunner a real head-turner,” said Taegen Clary, VP of Marketing at Unchained Labs. “Concentration is something they check constantly and DLS has been notoriously hard to use. Stunner makes it ridiculously easy to get these measurements at the same time on one system and literally makes DLS a push button activity.”
About Unchained Labs
Here’s the deal. We’re all about helping biologics researchers break free from tools that just don’t cut it. Unleashing problem-tackling products that make a huge difference in the real science they do every day. That’s our mantra, our promise and we own it. We’re located in Pleasanton, CA and can be found online at www.unchainedlabs.com.
Contact:
Taegen Clary
VP of Marketing, Unchained Labs
taegen.clary@unchainedlabs.com
925.587.9806
Download PDF of press release.
Aug 20, 2018
Unchained Labs just couldn’t take it anymore, frees the Big Kahuna! Read more.
Unchained Labs just couldn’t take it anymore, frees the Big Kahuna!
August 20, 2018 – Pleasanton, CA – Unchained Labs, the life sciences company that’s all about getting biologics researchers the right tool for the job, renamed its flagship workflow solution today. Freeslate is now the Big Kahuna.
“We really love this product and it deserved to be a part of the Unchained Labs family,” said Taegen Clary, VP of Marketing at Unchained Labs. “It’s always been the Big Kahuna to us and from here on out that’s what we’re going to call it.”
About Unchained Labs
Here’s the deal. We’re all about helping biologics researchers break free from tools that just don’t cut it. Unleashing problem-tackling products that make a huge difference in the real science they do every day. That’s our mantra, our promise and we own it. We’re located in Pleasanton, CA and can be found online at www.unchainedlabs.com.
Contact:
Taegen Clary
VP of Marketing, Unchained Labs
taegen.clary@unchainedlabs.com
925.587.9806
Download PDF of press release.
