Understanding all the reactions it takes to create a small molecule drug can be really challenging. Getting all the data and studying all the variables usually isn’t possible due to time and material constraints. Automated reaction optimization helps bridge the gap, allowing faster reaction setup and the scale down of reaction volumes. When your reaction is dependent on discrete variables like reagents, and the volume or mass of those reagents, the solution is pretty straightforward – scale down the reaction screening volumes. When you pile on continuous variables like time, temperature, and pressure, reaction optimization can get really tricky when trying to do this with standard automation solutions.
The right tool for the job
What the heck is an OSR?
Reactions in the OSR can start by turning on the gas line or adding catalyst or reactant through the injection port. Gas inlets are controlled so a discrete amount of your gas reagents can be added to each chamber and you can track how much is used. If you’re injecting a catalyst to kick it off, the needle bore is wide enough to pick up and transfer a slurry. Each reactor has an antechamber, so reagents can be dispensed without disrupting the conditions of the reactor. The OSR top is heated to keep your solutions in the vial. It also uses overhead stirring, so even if your solution becomes viscous after the reaction has started you can keep mixing.
Reactions on the OSR can be stopped quickly. The software automatically monitors each reactor by individual gas uptake or time. You can quench a completed reactor with the injection arm and continue to process or initiate other reactors. And if you’re trying to do a kinetic study, the injection arm does double duty as a sampling tool — taking advantage of the antechamber in the top to sample without disrupting the high-pressure, high-temperature reactions. This sampling capability lets you pull small amounts of your sample at different time points, so you can use analytical tools to determine reagent conversion, reaction endpoints and monitor impurity formation.
Junior automates all your back-and-forth, over and over again, hands-on work. Explore more reaction and formulation conditions, prep samples, or hand off any other tasks you think would be better performed if you’re not the one doing it.
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Every lab has different bottlenecks and challenges. We’re all about partnering with you to build the bespoke solution that lets you do science faster and better. Have questions or can’t wait to speak with our expert team to find out what might be possible?