Big Tuna


Big Tuna

Cut loose from manual buffer exchange

Buffer exchange is the time consuming, hands-on chore you have to deal with before all the things you really want to do. Big Tuna automates exchange to clean up, reformulate and concentrate proteins or gene therapy vectors like AAVs, LNPs, and VLPs. Skip the slow and manual ways of concentrating or buffer exchanging samples to free yourself up for other critical work. Get brochure.

1–96 formulations

0.1–192 mL sample

30 min hands-on time


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Go big or keep it small

Big Tuna serves up two consumables to tackle any volume requirement. Use Unfilter 96 to exchange as little as 100 μL on as many as 96 different samples at the same time. Unfilter 24 lets you go big and exchange as much as 8 mL on up to 24 samples. No matter how you roll, Big Tuna can handle it.

Always come out even

Big Tuna keeps buffer exchange even across the plate with its unique pressure-based UF/DF process and gentle mixing. Its acoustic sensor measures the volume in every well before and after each cycle to track every sample’s exchange rate. Then Big Tuna figures out on the fly how much buffer to add to even things out.

Be a control freak

Buffer exchange doesn’t have to be a shot in the dark or keep you anchored to the bench. Big Tuna gives you full, hands-off control over how efficiently the process happens. Take it slow and easy with delicate samples or fast-track the sturdy ones. Big Tuna nails the final concentration and gets you to next steps quicker.

Know it all

You’ll be a Big Tuna expert on the first try. Use the software wizard to drag and drop your samples and buffers into place — Big Tuna handles the rest. It’ll tell you exactly where to put everything else and how much buffer you’ll need. After the run starts, check in on progress anytime and know exactly when your exchange is done.