Posts by alison
Uncle raises the benchmark for protein characterization methods
Uncle raises the benchmark for protein characterization methods Blog With the meteoric rise of biologics as therapeutic medicines, establishing effective protein characterization methods has become more critical than ever. However, all these methods suffer from similar drawbacks. High-resolution techniques, like size-exclusion chromatography (SEC) or differential scanning calorimetry (DSC), take too much time and require specialized…
Read MoreHow to grab ADC DAR, concentration, and size on Stunner
How to grab ADC DAR, concentration, and size on Stunner Blog ADCs stopping your high-throughput characterization? Antibody-drug conjugates (ADCs) can put up major roadblocks when trying to accelerate to high-throughput characterization. UV/Vis spectroscopy is the simplest method for antibody concentration and drug to antibody ratio (DAR), but when the UV/Vis absorbance of an antibody and…
Read MoreLeprechaun takes the guesswork out of your lentivirus production
Leprechaun takes the guesswork out of your lentivirus production Blog Lentivirus production and purification can feel like navigating a maze. It is a complex, multi-step process following a standardized framework of harvest, clarification, filtration, chromatographic separation, and final polishing. Each step is essential for ensuring a high yield and purity of intact lentivirus, but lentivirus…
Read MoreCase Study: Columbia University reaping the benefits of automated process optimization
Scientists at Columbia University are reaping the benefits of automated process development with Sunshine Blog The challenge The immune synapse, akin to our immune system’s command center, dictates our body’s responses to threats. Scientists are exploring ways to manipulate it for improved disease treatments, particularly cancer and autoimmune conditions. Traditionally, protein manipulation was key, but…
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