Therapeutic Nanoparticles

Accelerate nanoparticle formulation screening, optimization and characterization with our primo solutions.

Researchers diving into the world of therapeutic nanoparticles (such as LNPs, polymer nanoparticles and liposomes) face tons of challenges on their way to making the next groundbreaking therapeutic. Picking the right payload, crafting a winning formulation, achieving optimization, then scaling up seamlessly for clinical trials is expensive, complex and a race against the clock. Day-to-day, you just need your precious payload encapsulated into high-quality particles pronto without burning through costly, single-use consumables. Add in the labyrinth of nanoparticle characterization — measuring encapsulation efficiency (EE%), size, PDI and nailing payload quantification — plus tedious clean up and concentration steps means nanomedicine development can feel like a constant uphill climb.

Our lipid nanoparticle solutions are tailor made for scientists to power through nanoparticle synthesis and characterization while ditching all the hassle. Sunscreen supercharges high-throughput payload encapsulation and nanoparticle formulation screening by generating up to 96 unique, low-volume formulations in under 6 hours – slashing through costs and time. With the winning formulations found on Sunscreen, researchers can hop straight to Sunshine for protocol development, optimization, and scale-up, all on a single instrument. When working with novel nanoparticles and no in-line dilution, Sunshine Lite has it handled. For a clean and simple approach to making individual low volume samples, Sunshine Single offers rapid walk-up and run nanoparticle production. Once it’s time for clinical trials, Sunbather suits up for nanoparticle production in GMP environments while using the same processes and microfluidic mixer (Sunny) that Sunscreen & Sunshine use. Nailing down nanoparticle characterization becomes a breeze with Stunner - getting fast, high-throughput, low-volume LNP encapsulation efficiency, concentration, sizing and payload quantification on up to 96 samples at a time. Once the perfect nanoparticle is formed, Unagi and Big Tuna take on the buffer exchange and concentration steps by automating the entire process using UF/DF.