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High-throughput protein stability measurements with Aunty
High-throughput protein stability measurements with Aunty Blog High-throughput protein stability measurements with Aunty When it comes to protein stability measurements, speed is king, but only if it comes with fidelity. Traditional stability methods have drawbacks: some are slow, don’t give the entire picture, or use too much sample. Aunty blasts through those issues to crank…
Read MoreHow to grab ADC DAR, concentration, and size on Stunner
How to grab ADC DAR, concentration, and size on Stunner Blog ADCs stopping your high-throughput characterization? Antibody-drug conjugates (ADCs) can put up major roadblocks when trying to accelerate to high-throughput characterization. UV/Vis spectroscopy is the simplest method for antibody concentration and drug to antibody ratio (DAR), but when the UV/Vis absorbance of an antibody and…
Read MoreLeprechaun takes the guesswork out of your lentivirus production
Leprechaun takes the guesswork out of your lentivirus production Blog Lentivirus production and purification can feel like navigating a maze. It is a complex, multi-step process following a standardized framework of harvest, clarification, filtration, chromatographic separation, and final polishing. Each step is essential for ensuring a high yield and purity of intact lentivirus, but lentivirus…
Read MoreCase Study: Columbia University reaping the benefits of automated process optimization
Scientists at Columbia University are reaping the benefits of automated process development with Sunshine Blog The challenge The immune synapse, akin to our immune system’s command center, dictates our body’s responses to threats. Scientists are exploring ways to manipulate it for improved disease treatments, particularly cancer and autoimmune conditions. Traditionally, protein manipulation was key, but…
Read MoreUpgrade your RNA quality control with Lunatic
Upgrade your RNA quality control with Lunatic Blog RNA is the key component for all kinds of therapeutic and analytical applications. However, contaminants show up in RNA preps no matter the RNA source and these contaminants can interfere with anything from gene expression assays to creating RNA-LNPs. Proteins and genomic DNA often show up in…
Read MoreSneak a peek at AAV aggregation and titer with Stunner
Sneak a peek at your AAV aggregation and titer with Stunner Blog Quantifying adeno-associated virus (AAV) titer and checking for aggregates are major challenges for developing and manufacturing these gene therapy vectors. The classic AAV tools include chromatography, AUC, TEM, ELISA, and PCR-based methods, but none of these deliver results quickly, easily, and from low…
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