Sunscreen
The primo nanoparticle synthesis platform for high-throughput formulation screening
Crank out automated nanoparticle formulation screening
Sunscreen automates nanoparticle formulation screening using microfluidics to rapidly generate low-volume nanoparticle samples. With automated reagent handling, sample collection and in-place cleaning, it produces highly consistent, ready-to-test particles in minutes - so you can screen more payloads and formulations than ever before. Get brochure.
- Microfluidic precision: Generate uniform nanoparticles with supreme consistency in controlled microfluidic flow paths – less than 1% CV over 90 runs. Â
- Low reagent consumption: Run 400 µL (3:1 ratio) experiments with as little as 100 µL per reagent input, minimizing material waste while maximizing data.Â
- Range of reusable mixers: Sunnies (microfluidic mixers) come in a range of geometries and are manufactured from glass and automatically cleaned in place after every experiment, keeping running costs and hands-on time minimalÂ
- No cross contamination: Automatic cleaning of all wetted parts of the system between every experiment ensures no reagent carry-over and guarantees high-integrity samples.Â
- Scale-ready results: Sunscreen uses the same pumps and mixers as Sunshine and Sunbather, ensuring seamless process transfer from screening to GMP.Â
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Watch Sunscreen in action.
Find your flow
With your plates loaded, you’re ready to mix up your nanoparticles with a Sunny. Sunnies are infinitely reusable and come in a range of geometries and sizes, with 9 different options to suit any application. Sunnies can be swapped in seconds, are cleaned after each experiment and when you’re ready to turn up the volume they can run longer than you can.
Set it, forget it
Tell Sunscreen’s Sunny Suite Software what’s in your plates, the mixing ratios, flow rates, and you’re ready to go. Built-in validation checks each experiment so that your run goes off without a hitch. With an entire plate of nanoparticles knocked out way before the day is done, you’ll still have plenty of time to start buffer exchange or characterization ahead of clocking out.
Do more with less
Nucleic acids typically cost a ton and are difficult to make. Sunscreen lets you flex concentrations and volumes to use way less of these precious payloads, saving lots of dough while you hunt for the MVPs. Add in reusable consumables and less than 15 minutes of instrument hands-on time to make 96 formulations, and you’ll walk away with your winners in no time.
Bank on it
When Sunscreen churns out a plate, you can trust that each formulation will be made consistently. Automated washing between experiments ensures no carryover from the last formulation, so a not-so-good formulation won’t affect the next good one. If you really want to supercharge your workflow, grab Stunner AF (Add Fluorescence) to check on your particle size, payload quant, and encapsulation efficiency to suss out your winners.
Narrow it down
Sunscreen helps you test a ton of formulations so you can sort the good from the bad, finding the right formulation combo to nail the payload and particle delivery performance you need. When you’re ready to optimize the killer top-tier formulations you find on Sunscreen, they can be transferred directly to Sunshine and on to Sunbather – the Sunny too.
End-to-end with the Sunny Suite
The Sunny Suite has a killer solution for every step of your nanoparticle development. Sunscreen automates high-throughput screening of up to 96 formulations, then Sunshine homes in on the perfect mixing process conditions, with both automated experiments and continuous flow modes. When you’re ready for clinical trials, Sunbather dials up your particles in a fully GMP-compliant environment.
Trust the process
With identical fluid delivery and microfluidic mixing at every stage, the Sunny Suite makes for smooth sailing in every transition from formulation screening to process development to GMP production. Whether you’re screening through hundreds of formulations or producing liters of particles for clinical trials, the Sunny Suite’s the total package.
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App Notes
Ben Knappett, PhD, Product Manager, LNP Solutions, Unchained Labs                                                     Arpan Desai, Managing Director, NanoVation Therapeutics UK     Graham Hayes, PhD, Senior Scientist, NanoVation Therapeutics UK
Specifications
| Application | |
|---|---|
| Throughput | 3-4 minutes per sample, up to 96 samples |
| Total flow rate range (Sunny dependent) | 0.1–30 mL/min |
| Typical sample volume (3:1 FRR) | 0.4–2 mL |
| Minimum input volume (including dead volume) | ≥105 µL |
| Continuous mode | No |
| In-line dilution | Yes |
| Flow rate ratio range (aqueous to organic) | 1:1 to 5:1 |
| Typical particle size range | 40–200 nm* |
| PDI | <0.2* |
| Encapsulation efficiency | >90%* |
| Instrument | |
|---|---|
| Physical | |
| Weight and dimensions (cm) | 57 kg, 60 H x 90 W x 40 D |
| Electrical | |
| Voltage input | 100 V–240 V AC, 50-60 Hz |
| Communications | USB |
| Other Information | |
| Sample loop size | 2.5 mL |
| Fluid store volumes | 4 x 1000 mL bottles |
| Wetted materials | PTFE, PCTFE, FEP, ETFE, PEEK, Polypropylene, FFKM, Hastelloy C276, Stainless Steel T316, Glass, Tygon (waste tubes), HDPE (waste container) |
| Computer | Separate computer with Win 11, monitor, keyboard and mouse (not included in dimensions) |
| Consumable | |
|---|---|
| Sunnies | Glass microfluidic mixing devices of various geometries and channel sizes |
| Available types | Sunny 490 Trident T, Sunny 100 X, Sunny 100 T, Sunny 190 X, Sunny 190 T, Sunny 275 X, Sunny 275 T, Sunny 150 3D, Sunny 50 Micromixer |
