Lunatic
The low-volume, plate-based UV/Vis tool for biologics & genomics
Get your quantification on with UV/Vis
Lunatic delivers high-throughput, low-volume UV/Vis absorbance data from just 2 µL per sample across up to 96 wells of an SBS format plate. It precisely quantifies proteins, DNA, and RNA in minutes - revealing both concentration and purity without dilutions or extra prep. Get brochure.
- Protein quantification: Measure protein concentration across an unmatched range of 0.03–275 mg/mL with full-spectrum UV/Vis data - ideal for formulation, conjugation, and purity checks.
- Nucleic Acid Concentration: Quantify DNA or RNA from 1.5–13,750 ng/µL with precision, no dilutions needed — critical for genomics workflows and QC.
- Contaminant detection: Identify and quantify impurities like buffer components or co-purified proteins using Unmix deconvolution algorithms — ensuring your results are clean and reliable.
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Videos
Scope protein quant with Lunatic
Scope protein quant with Lunatic
Watch nucleic acid quant with Lunatic
Watch nucleic acid quant with Lunatic
Check out compliant-ready biologics quant with Lunatic
Check out compliant-ready biologics quant with Lunatic
No B.S. workflow
Skip the sample prep, cleaning and worrying about cross-contamination or evaporation – your samples will sit tight for up to 2 hours. Our Lunatic UV/Vis plate reader runs 96 samples in 10 minutes. Each microfluidic circuit has two fixed pathlengths built-in to cover a wide dynamic range of 0.03-275 OD. All you do is load up your samples and get kick-ass results.
Max out your biologic
Lunatic is the only UV/Vis spectrophotometer out there that can measure biologics at high-throughput and high concentration. It’s got dynamic range that covers from 0.02 mg/mL to 200 mg/mL (mAb), so run any protein without ever having to dilute again. Stop the madness of running just one protein at a time — and cleaning up afterwards.
Ridiculously good data
Get spot-on precision within 1% and accuracy within 2%. Using two fixed path lengths, Lunatic gets you jaw-dropping data at both low and high protein concentrations and nails the expected concentrations every time. With the smallest sample size, the highest throughput and crazy accurate results, Lunatic is hands down the best uv/vis spectrophotometer out there for protein quantification.
Accuracy you can show off
Lunatic has shocking accuracy and wants to prove it. Using the Fundamentals tryptophan standards, the accuracy, precision and linearity of the instrument can be proven at any time — at the protein-relevant 280 nm wavelength and OD range of 20-225. Be confident about every sample with data that leaves no room for doubt.
Downstream ready
Smash through the USP & Ph. Eur. UV/Vis requirements for absorbance accuracy, precision, linearity, wavelength accuracy, stray light and resolution with performance verification measurements of independently certified NIST standards. Lunatic is ready when you are to get validated and make the move into QC.
Put it on lockdown
GLP labs don’t sweat it. Lunatic’s software hooks labs up with 21 CFR Part 11 compliant features. We’re talking password protection, electronic signatures, full audit trail — the whole package.
Dig up your genomic’s dirt
DNA and RNA samples can be freaking messy. Lunatic analysis software lets you see annoying impurities that classic A260 measurements alone mistake as your DNA or RNA. Find out exactly how much RNA, turbidity, beads and other influencers are screwing up your nucleic acid quantification. Ditch the time-sucking, dye-based prep and know right away if your samples are good to go.
Set it and forget it
Lunatic talks to robots. Hook it up with any liquid handler system and run your measurements completely hands-off with our API setup and keep more of your precious sample for the rest of your workflow.
Tech
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Specifications
| Lunatic instrument specifications | ||
|---|---|---|
| Dimensions | 37 cm W x 46 cm D x 33 cm H; 21 kg | |
| Operating voltage | 24 VDC, 30 W (max) | |
| Connection | USB, TCP/IP (Service, SiLA) | |
| Light source | Xenon flash lamp | |
| Detectors | UV/Vis polychromatic spectrophotometer | |
| Approval | CE, FCC, CSA | |
| Wavelength range | 230-750 nm | |
| Wavelength accuracy | ≤400 nm: ±1 nm; ≥400 nm: ±2 nm | |
| Spectral resolution | Better than 2 nm (toluene in hexane) | |
| Absorbance precision (1 cm quartz cuvette) | <1 OD: ±0.005 OD st dev | 1-2 OD: ±0.5% CV |
| Absorbance accuracy (1 cm quartz cuvette) | <1 OD: ±0.01 OD | 1-2 OD: ±1% |
| Lunatic plate specifications | High Lunatic Plate | Lunatic Plate |
|---|---|---|
| Application area | High concentration samples, typically proteins | Low concentration samples, typically nucleic acids |
| Sample retention time | Up to 2 hours | Up to 2 hours |
| Recommended sample volume | 2 µL | 2 µL |
| Pathlength(s) | 0.1 mm & 0.7 mm path | 0.5 mm path |
| Measurement time for full plate | ~10 minutes | ~5 minutes |
| Measurement range: OD 10 mm ng/µL dsDNA mg/mL ave protein mix | 0.03–275 OD 10 mm 1.5–13750 ng/µL 0.03–275 mg/mL | 0.03–40 OD 10 mm 1.5–2000 ng/µL 0.03–40 mg/mL |
| Absorbance precision (10 mm pathlength) | <1 OD: ±0.01 OD st dev 1-200 OD: ±1% CV | <1 OD: ±0.01 OD st dev >1 OD: ±1.5% CV |
| Absorbance accuracy (10 mm pathlength) | <1 OD: ±0.02 OD 1-200 OD: ±2% | <1 OD: ±0.02 OD >1 OD: ±4% |
| Dimensions | 8.55 cm W x 12.8 cm D x 1.21 cm H | |
| Samples per plate | 96 (12 x 8 microplate format) | |
