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Nunchuck

The one-and-done LNP maker

Get sweet nunchuck skills

Nunchuck is the first and only platform that combines two key steps needed to make the perfectly-sized LNP – total flow rate screening and lipid nanoparticle formulation. Screen 8 total flow rates (TFRs) in just 10 minutes to find your sweet spot fast, then jump straight into making 0.5 to 200 mL of your LNPs. Dump the one‑flow-rate-at-a-time, back and forth workflows for the ultimate one-and-done LNP maker. Get brochure.

  • 50 – 200 nm size LNPs
  • Screen 8 TFRs in 10 min
  • 0.5 – 200 mL formulations

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The nun gets it done

Load your syringes filled with aqueous and organic solutions into Nunchuck, lock them into the Nun consumable, and you’re ready to start making LNPs. The Nun’s novel microfluidic mixing chambers can handle flow rates from 0.5 to 30 mL/min which means it can create a wide range of LNP sizes. Plus Nunchuck’s camera watches for the flow to start, so you capture as many LNPs as possible.

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White belts welcome

Nunchuck is so easy to use a newbie can kick off a run in minutes. First, choose either a screening or prep run, then enter all the details about your formulation. The last step is to choose your flow rate ratio, total flow rates, and desired sample volume. You’ll be an LNP black belt in 5 minutes flat.

Hit your target

Depending on your target, you’ll need to make different sizes of LNPs. Dialing in the total flow rate (TFR) is one of the most time-consuming steps for getting the size right. Nunchuck is outfitted with a fit-for-purpose screening run that nails down your TFR in 10 minutes. Screen up to 8 total flow rates with crazy repeatability so you can find your optimal conditions without breaking a sweat.

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Level up

It doesn’t matter if you need 0.5 mL or 200 mLs – Nunchuck gets you the same high‑quality LNPs at any volume. Forget using one instrument to optimize your sample and another to make enough to characterize and develop your LNP formulations, Nunchuck always has your back.

Learn more

Webinars

Earn your black belt with Nunchuck’s LNP making skills

Martha Perez, PhD, Marketing Director, Unchained Labs

App Notes

Screen and prep LNPs with Nunchuck
Nunchuck’s fluidic path chemical compatibility

Technology

Microfluidic Mixing

Want a quote or a demo?